In South America, traditional spiritual substances such as Ayahuasca, Kambo, and Rapé hold a central place in the indigenous spiritual practices. Ayahuasca, a powerful psychoactive brew, is renowned for facilitating profound spiritual experiences and healing. Kambo, derived from frog secretions, is used in cleansing rituals, believed to detoxify the body and strengthen the immune system. Rapé, a sacred herbal snuff, is utilized for its ability to induce deep spiritual insights and promote physical and emotional healing. These substances, deeply respected and used with reverence, embody the rich spiritual heritage of South American indigenous cultures, offering a unique window into their understanding of the interconnection between nature and spirituality.