Ayahuasca, a South American psychoactive brew, has traditionally been used for spiritual ceremonies and healing by Indigenous cultures in the Amazon and Orinoco basins. Initially limited to Peru, Brazil, Colombia, and Ecuador, its use spread across Brazil by the mid-20th century with the rise of syncretic religions like Santo Daime and União do Vegetal, which incorporate Amazonian Shamanism, Christianity, Spiritism, and African-Brazilian religions. Ayahuasca’s popularity has since expanded globally, reaching the United States, Western Europe, and other regions.
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